Premature Ovarian Failure (POF), also to as referred as premature ovarian insufficiency, is a condition in which the patient loses her ovarian function before the age of 40. There are many reasons for POF; however, the causes of many cases are still not confirmed. They may cause a decrease in the storage of follicle pools or a malfunction of follicles.


1. Genetic factors: the main cause of POF. An abnormal X chromosome is generally regarded as the main cause of POF.

2. Immune factors: POF patients are commonly associated with at least 2 kinds of immune disorders, and thyroid disorders are the most commonly noted complications with POF.

3. Surgery, chemotherapy, radiotherapy and toxic factors of the environment.

4. Enzyme deficiency: deficiency of some special enzymes can affect the synthesis of estrogen, which further causes prolonged puberty, primary amenorrhea, as well as leveled up gonadotropins.

5. Idiopathic POF.


POF is frequently noted in women aged in 20-30 who have had a normal childbearing history, but were suddenly attacked with amenorrhea, or they may have been troubled with poor menstruation and the condition gradually worsened, leading to amenorrhea over a long period of time. In some cases, the patients had menstruated once or twice after the menarche but suffered from amenorrhea as a result. Such young patients usually visited the doctor due to vaginal dryness, difficulty in sexual intercourse and infertility. As a result of low estrogen level, patients often complained of perimenopausal symptoms, such as hot flushes, sweating, upset moods, irregular periods, retrograde development of the secondary sex characters. The POF symptoms in menstruation are usually less or little menstrual volume, or even complete amenorrhea and infertility.
Generally, POF patients experience different degrees of perimenopause symptoms like hot flushes, sweating, upset moods, decreased sexual desire, easily getting angry and catching colds. Patients suffer from premature ageing, which is not only painful, but damaging to the psychology and also sometimes their personal relationships.

Treatment for Premature Ovarian Failure in ReLife

Hormone replacement will be initiated when a patient is diagnosed with POF due to the estrogen deficiency. Medication like Calcium and vitamin D supplements will also be applied. For patients developing the complication of fertility problems, addressing infertility is also included in the treatment plan. Nowadays, as new medical techniques like gene therapy and stem cell therapy are applied more frequently, the treatment of POF has a prosperous future due to the new innovative techniques.

Cell-based Gene Therapy for Premature Ovarian Failure

Utilizing the molecular biology method, cell-based gene therapy is an innovative treatment method that implants the hepatocyte growth factor – HGF via autologous cells into the patient’s body. By targeting the damaged ovary, it continuously and stably repairs the patient’s ovary, so as to eliminate the inner factors that cause POF and achieve the best treatment result.

Adipose tissue is an active endocrine and paracrine organ, which secretes various cytokines and biological factors. The regular secretion of adipose tissue regulates and controls the balance of energy in body, and also plays a role in many procedures, such as anti-inflammation. Adipose tissue is full of adipose stem cells, which have the ability to be easily cultivated in vitro and multiple differentiation capacity. It can effectively participate in the regenerative and repair procedures of the damaged ovary.

By taking advantage of adipose stem cell tropism, HGF will be carried into the damaged ovarian region by adipose stem cells, enabling HGF to continuously and stably affect and improve the blood circulation, as well as improve the survival rate and efficiency of adipose stem cells, which makes the treatment effect much better than a single application of stem cell therapy. It plays a key role in overcoming reproductive disorders, repairing the impaired ovarian function, and promoting the balance of endocrine system.

Traditional Chinese Medicine

Traditional Chinese Medicine is a green, safe and effective treatment method. Via acupuncture, traditional Chinese medicine, moxibustion and natural therapy, TCM can activate the positive Qi in the human body, promote the gonad axis to work normally, recover the ovarian function, improve the endocrine function as well as the general internal environment of body, and recover the functions of both the Chong channel and Ren channel. By adjusting the hypothalamus-pituitary-gonad (HPG) axis, it can recover the ovarian function, thereby achieving the balance between Yin and Yang, Qi and Blood, as well as the organs, which further benefit the recovery of the gonad axis function and the correction of POF.


POF is such a difficult issue in medical field that many researchers still have not found an effective treatment method for it; however, the unique combination treatment of advanced gene therapy and Traditional Chinese Medicine for POF at ReLife International Medical Center, based on each patient’s condition, has smooth, effective and continuous treatment effects, with much less pain during the treatment procedure. Our treatment is designed according each individual case. It is quite flexible and is performed regarding to each patient’s body condition and exact disease details.

It can improve the human body overall, make the endocrine system become balanced quickly, and regulate the energy balance in the human body, thereby strengthening the function of the hypothalamus-pituitary-gonad (HPG) axis and can treat the POF condition with exciting results.